Wreckage of EgyptAir flight MS804 has been found south of the Greek island of Karpathos, Egyptian aviation officials confirmed.
The Airbus A320 was en route from Paris to Cairo with 66 passengers and crew when it went down overnight.
Egyptian Vice-President Ahmed Adel told CNN the rescue operation was “turning into a search and recovery”.
Officials say the plane is more likely to have been brought down by a terrorist act than a technical fault.
It made two sharp turns and dropped more than 25,000ft (7,620m) before plunging into the Mediterranean Sea, Greek Defence Minister Panos Kammenos told reporters.
Search teams in the area have sighted debris from the plane, including life jackets.
“There have been finds south-east of Crete, inside the Cairo flight information area,” Greek army general staff spokesman Vassilis Beletsiotis told AFP news agency.
The search in seas south of the Greek island of Karpathos involves Greek and Egyptian naval forces, and the British Royal Air Force.
Sixty-six people were on board Flight MS804, most of them from Egypt and France. A Briton was among the passengers.
Of those on the plane, 56 were passengers, seven were crew members and three were security personnel.
Relatives of some of those on board are being flown from Paris Charles de Gaulle airport to Cairo.
Flight MS804 left Charles de Gaulle at 23:09 local time on Wednesday (21:09 GMT) and was scheduled to arrive in the Egyptian capital soon after 03:15 local time on Thursday.